
Living with chronic hives with no known external triggers
Patient portrayal.
What is chronic hives with no known external triggers?
Chronic spontaneous urticaria (CSU), or chronic hives with no known external triggers, is a condition marked by itchy hives, swelling, or both lasting more than 6 weeks. It was previously called chronic idiopathic urticaria (CIU), since the symptoms seemed to appear without a clear cause. Recent research suggests the immune system may be involved, setting off symptoms without anything external—like a food or allergen—causing them. That’s what makes chronic hives with no known external triggers different—it’s thought that the immune system is acting on its own, setting off symptoms from within.
It's more than skin deep
It’s hard when hives flare up unexpectedly. They can take over your days—or nights. But there are tools and support available that can help you.
Explore resources that offer support and strategies for living with chronic hives with no known external triggers.
When antihistamines alone aren’t enough
Antihistamines are the first line of treatment for chronic hives with no known external triggers. But when one doesn’t work, you try another—and another. But even with higher doses, the itching and flares may come back.
Help break the cycle of CSU with RHAPSIDO® (remibrutinib)
If antihistamines alone fall short, ask your doctor about RHAPSIDO. RHAPSIDO should not be used to treat any other forms of hives.

"I encourage people living with this condition to speak up about their needs. Ask questions and seek support."
– Lauren, a real patient living with CSU taking RHAPSIDO
Your CSU journey matters.
If you would like to share your experience with chronic hives with no known external triggers and treatment with RHAPSIDO, please contact us at [email protected] or call 1-877-879-0245. A member of our Voices of Inspiration team will reach out to connect.
